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The three individual Projects and four Cores revolve around the development,
application, interpretation, and presentation of high resolution multidimensional
images of the developing nervous system obtained on several model systems
both in vitro and in vivo. The collaborators bring a number of different
philosophies and types of expertise: computer graphics, modeling and control
theory; mapping brain physiology/function and cortical learning; embryology,
cell and molecular biology, and digital optical microscopy; microscopic
resolution MRI. 
Goal-Based Algorithms for 3D Analysis and Visualization Project [Algorithms
Project]
Al Barr and David Laidlaw
The goal of this Project is to develop and implement methods from computer
graphics in order to extend the state of the art in data collection, modeling,
analysis, and visualization of three-dimensional information about the
developing brain. This project continues the development of teleological
(i.e. "goal-based") methods that facilitate both the acquisition and
analysis of multi-valued multi-dimensional MR and optical images. The
intrinsically high density of information in these images points out the
need for novel ways of looking at it and novel ways of making it publicly
available. One of the major thrusts of this Project is the development,
testing, and validation of new algorithms for the understanding of multi-valued
multi-dimensional data sets. These involve:
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tools for tissue discrimination that will be essential for brain atlas
annotation,
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hardware and software aimed at semi-immersive visualization, as well as
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whole new approaches to data rendering, such as "painterly" visualization
where the essence of the image is
emphasized and the nuances are retained.
The dissemination of the annotated multi-valued multi-dimensional atlases
of development presents a formidable challenge. Subsets of the visualized
data will be distributed through normal publications and via the Web. More
complete data sets will be distributed on CD-ROM with sophisticated visualization
tools available through the Web.
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